Prednisone vs. Prednisolone for Ulcerative Colitis


ulcerative colitisWhen it comes to ulcerative colitis, there are various treatment options. Many different types of medications are available. The treatment that your doctor prescribes for you often depends on the severity of your symptoms. Two drugs that you can hear about are Prednisone and Prednisolone. Here, you will find what these drugs are and how they can help you to treat ulcerative colitis, taking into account their common and distinctive features.


Prednisone and Prednisolone Comparison

Both drugs Prednisone and Prednisolone are used internally in a suitable combination with cortisone and hydrocortisone in a dose of 1 / 4-1 / 5 of Prednisolone. Prednisone is fully effective at an initial dose of 40 mg per day divided into 3 doses, while Prednisolone is effective at a dose of 30 mg per day divided into 3-4 doses.

The composition of the drug Prednisolone contains 5 mg of the active compound. About the medicine Prednisone, it is possible to say that it is a structural analogue of Prednisolone. It contains the same component, but in a different volume. This is the first difference between medicines.

Prednisolone is a synthetic agent - an analogue of the hormones cortisone and hydrocortisone, which are secreted by the adrenal cortex. Prednisolone with colitis when ingested has a 4-5 times greater activity. The drug will not cause noticeable delays in the release of sodium and water, but can only slightly increase the release of potassium.

Tablets of Prednisone can contain 1, 5, 20 or 50 mg of substance. The second difference is in their price. The instructions for use position drugs as analogues. However, despite the fact that they have a similar composition, the price is very different.

Treatment of Ulcerative Colitis with These Drugs

Nonspecific ulcerative colitis is a disease of an unknown etiology, characterized by a chronic inflammatory process in the colon with the development of hemorrhage, ulceration and pus formation.

The main pathogenetic mechanisms of the disease are: immunological disorders and autoimmunization; development of dysbacteriosis; allergic reactions; genetic factors; neuropsychiatric disorders; increasing the level of pro-inflammatory prostaglandins and leu-cotrienes in the mucosa of the colon, which contributes to the development of an intensive inflammatory process in it.

Prednisone and Prednisolone belong to the class of drugs called glucocorticoids. Glucocorticoids reduce inflammation throughout the body. They do this by interfering with how some chemicals in your body cause inflammation. These drugs can work in different parts of your body, including the colon. By reducing inflammation, these drugs help reduce the damage that colitis has on your gut.

None of these drugs cure colitis but both can help control it and improve the quality of life.

These drugs remove common symptoms, such as:

Prednisolone is prescribed in the initial dose of 40-60 mg per day. Such high doses of prednisolone should be used until the improvement reaches its plateau or complete remission occurs. In patients who have a good effect from such treatment, the dose of prednisolone should be reduced to 5 mg per week. In patients with insufficient effect from treatment with steroid hormones, a gradual withdrawal of prednisolone within several weeks or months is carried out.

If the main substance Prednisolone is well-tolerated, therapy in the prescribed dose is recommended until the desired result is achieved (within 3-4 weeks), after which the dose is reduced in a stepwise scheme - by 10 mg every 5-7 days. Starting with 1/2 of the initial dose, a single dose of prednisolone is recommended in the morning hours, which practically does not cause serious complications.


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