Discomfort in the back may be caused by different reasons. To establish the cause of discomfort in the back is extremely difficult, therefore, it is better not to delay this problem and immediately consult a doctor. The right diagnose is the key to a quick recovery. Prednisone is a drug from the group of hormones of the adrenal cortex (glucocorticosteroids) able to help to get rid of back pain effectively. It contains the substance prednisolone, which is able to contribute to the pain removal.
Find out how exactly Prednisone can help you when having back pain.
What is low back pain?
The low back pain is called the pain in the back part from the lower part of the thorax to the coccyx. Pain in the lower back is very common. According to statistics, from time to time, pain in the lumbar region is experienced by about 90% of people. Sometimes the cause of pain is overexertion - for example, after too intense training or after a long stay in an uncomfortable position. But in some cases, it signals about serious violations in the body.
On the lower back, there is a very heavy load. In the supine position, the intervertebral discs undergo pressure of 50 kg, while in the standing position it is 100 kg, in a sitting position with a straightened back without support - 150 kg, and if the person sits not straight - 220 kg. Intervertebral discs in this area are particularly vulnerable and wear out faster than in other parts of the spine. Therefore, with any unpleasant sensations in the lower back, you should immediately seek medical advice to avoid more serious problems with the spine.
The pain can be various: acute, blunt, drawing, burning, can be accompanied by pricking and tingling, numbness. The intensity of low back pain can vary significantly - from weak to unbearable pain, which prevents even a small movement. Pain can be combined with pain in the thigh, pain in the lower leg, pain in the foot.
Sharp pain in the lower back to the primary and secondary. As for the causes of primary pain in the lower back, it is due to the development of pathology in the spinal column. So, there are functional and dystrophic changes in vertebral joints, muscles, intervertebral discs, ligaments and tendons. The spine is a series of vertebrae, which are connected together by a complex of elastic tissues, ligaments and muscles. In addition to bone tissue, there are also nerve endings, which become a source of development of back pain.
Is Prednisone effective for back pain?
Prednisone refers to glucocorticoids, which are hormonal drugs that are derived from cortisol, a natural human hormone produced by the adrenal glands. Steroid drugs have a pronounced anti-inflammatory effect eliminating the inflammatory process. Prednisone intake contributes to the elimination of pain. The anti-inflammatory effect of glucocorticoids is due to several factors. In particular, the drug contributes to a decrease in the production of the enzyme COX-2, which is responsible for the production in the inflammation zone of specific biologically active substances, which are also called mediators of inflammation.
In addition, it improves microcirculation processes in the inflammatory focus, thereby reducing tissue edema. Why is it important to remove swelling? Because with osteochondrosis, edema of tissues leads to compression of the nerve roots leaving the spinal cord, which leads to the development of pain syndrome. In addition, Prednisone has the ability to stabilize the membranes of cells and cellular structures.
Due to this, the process of destruction of lysosomes and the entry of lysosomal enzymes into the focus of inflammation are reduced. Also, glucocorticoids can block the activity of collagenase (a substance that destroys collagen), thereby reducing the course of destructive processes in the intervertebral joints. Depending on the duration of the action of glucocorticoids are divided into drugs. Prednisone belongs to the average duration of action.
Getting into the systemic circulation, Prednisone goes to the affected tissues, penetrates into specific receptors and causes a number of chemical reactions. As a result, the patient has analgesic and anti-inflammatory effects, anti-edematous and antitoxic effect, as well as the drug helps to strengthen and accelerate the work of other medications used in the treatment of diseases of the spinal column.
How to use Prednisone 20 mg for back pain?
Prednisone for back pain should be taken orally, swallowing whole and with enough liquid. Initially, the drug must be taken at 20 mg per day to achieve a therapeutic effect (improving the patient's condition). Then, gradually reduce the dosage to 5-10 mg per day. In extreme cases, the initial dosage can be increased to 50-100 mg per day, and up to 15 mg per day.
The maximum daily dosage is 100 mg, single dose is 15 mg. Children are prescribed the drug depending on the weight of the patient - 1-2 mg per kg per day, dividing into 4-5 receptions. The maintenance dosage is 300-600 mg per kg per day.
The course of back pain treatment is individual. It may vary but usually it is about several months. Cancellation of the drug should be done gradually.
Prednisolone 20 mg active substance of Prednisone is well absorbed from the gastrointestinal tract. The maximum concentration in the blood is reached after 1-1.5 hours after oral administration. Up to 90% of the drug binds to plasma proteins: transcortin (cortisol-binding globulin) and albumins. Prednisolone 20 mg is metabolized in the liver, partially in the kidneys and other tissues, mainly by conjugation with glucuronic and sulfuric acids. Metabolites are inactive. It is excreted with bile and urine by glomerular filtration and is reabsorbed by tubules by 80-90%. 20% of the dose is excreted by the kidneys unchanged. The half-life from plasma after oral administration is 2-4 hours.
Can I take Ibuprofen with Prednisone?
Ibuprofen reduces pain, lowers the temperature for arthrosis, rheumatoid arthritis and back and spine pain and splits during two days. Prednisone is prescribed for rheumatic diseases and acute stages of inflammation of the joints. With the long-term admission together with other medicines for rheumatism, it can cause gastric diseases, and with simultaneous administration of anticoagulants - severe internal bleeding.
In certain cases, these two drugs can be combined. However, this is not the most safe combination. According to the instructions, the combined intake of ibuprofen and glucocorticosteroids, among which prednisone is, can increase the risk of gastrointestinal ulcers and gastrointestinal bleeding. Take this into account and consult your doctor before you take two drugs together.
Prednisone for animals
The use of Prednisone (Prednisolone) for dogs and cats
Prednisone is used to treat dogs and cats in inflammatory processes, Addison's disease, nervous system disorders, and malignant tumors.
Prednisolone and Prednisone are steroid hormones that reduce inflammation and suppress the immune system of cats, dogs and other animals.
Prednisone and Prednisolone may be helpful in treating many diseases and disorders, but minimal doses and duration should be used to reduce the development of any side effects.
In shock, glucocorticoids are used in high and ultra-high doses. These drugs can also be used to assist animals in the treatment of Addison's disease, cancer, shock, and various nervous system disorders.
The drugs Prednisone and Prednisolone play a special role in the treatment of dogs in the development of anaphylactic shock and / or anaphylaxis. Glucocorticosteroids can be useful for carditis of various etiologies, but with the development of congestive heart failure, their use will bring more drawbacks than advantages.
When animals develop cardiogenic cachexia, prednisone and other glucocorticoid hormones can be prescribed to stimulate appetite and slow down the depletion process. In any case, the veterinary doctor must evaluate all the positive and negative aspects of the treatment of animals with Prednisone and Prednisolone.
The mechanism of action of drugs from the group of Prednisolone on the animal organism
Prednisolone is a corticosteroid (glucocorticoid). Corticosteroids are designed to replace the natural hormone produced by the adrenal cortex, cortisol. Corticosteroids act on the immune system of animals, blocking the production of substances that cause inflammatory and autoimmune reactions.
In your pet's liver, prednisone is converted to prednisolone. Domestic animals with serious liver problems do not experience this transformation, and many people believe that these pets should be treated only with Prednisolone.
What to do if the next dose of Prednisone for an animal is missed?
It is important to try not to miss the introduction of this drug. You should give hormones every day, at about the same time, at regular intervals. If you miss another dose of prednisone, give it as soon as possible.
If it is time for the next dose, do not use the missed dose and continue the treatment previously prescribed. You should not give your pet a double dose of Prednisone immediately.
Prednisone and diabetes
The drug Prednisone has a number of contraindications and one of them is diagnosed diabetes. Patients with this condition are required to refrain from using Prednisone, which is available in tablet form as well as injectable solution. If this is unavoidable, then the diabetic should carefully study the features of treatment with Prednisone.
Prednisone has a pronounced anti-inflammatory property, also contributes to the removal of toxic substances from the body and reduce allergy symptoms.
The drug Prednisone is involved in supporting the immune system and cleansing the digestive tract from allergic agents. This medicine has anti-shock effect, which helps to cope with anaphylactic shock, accompanied by prolonged loss of consciousness.
With the help of Prednisone, it is possible to eliminate the increased vascular permeability and prevent the release of fluid into the tissues that occurs during inflammatory processes.
How to apply Prednisolone and its dose?
The correctness of the reception of the drug Prednisolone is established by a qualified doctor. The drug Prednisone (Prednisolone) is prescribed individually for each patient in a dosage depending on the diagnosis and the severity of the disease.
The daily dosage of Prednisolone for adults is 4-60 mg intravenously or intramuscularly. The duration of treatment and the number of injections is determined for each patient separately. Prednisolone tablets are taken orally once a day, preferably in the morning. At the discretion of the physician, the prednisolone pills can be increased. Treatment should be stopped gradually, reducing the dosage of Prednisolone to the minimum effective values.
Contraindications for Prednisone. Diabetes and other conditions
It is not recommended to use Prednisone to treat patients with individual intolerance to the components of this drug, as well as to those who have been diagnosed with gastric ulcer, viral infections, osteoporosis, high blood pressure.
Prednisone can harm and aggravate the patient's condition if taken in case of impaired kidney function, diabetes mellitus, active tuberculosis, cataract, and systemic mycosis. Prednisone is contraindicated in women carrying a child and nursing mothers.
Can Prednisolone be used with diabetes?
Prednisolone, like any medical drug of the glucocorticoid group, can raise blood sugar levels and thus adversely affect the course of diabetes.
If it is not possible to replace the treatment, then for diabetics, doctors may recommend lower dosages of Prednisolone. In the event of their ineffectiveness, as well as the inability to use a drug similar in pharmacological action, the patient is prescribed Prednisone, but subject to regular monitoring of blood sugar levels. Such precaution is necessary in order to adjust the dosage of medicines aimed at reducing the concentration of sugar in the blood.
Prednisone for gout
Gout is a disease associated with an excess of uric acid in the body and the deposition of its salts in the tissues (mainly in the kidneys and joints). Currently, it is impossible to completely cure gout. This disease forces you to take medication continuously throughout your life.
Prolonged use of drugs that normalize the level of uric acid in the blood is the basic principle of the treatment of gout, since the withdrawal of drugs leads to the resumption of attacks of the disease.
There are two ways to treat gout:
- treatment of an acute gout attack;
- permanent anti-gout treatment.
Treatment of acute gout
The treatment of an acute attack of gout is carried out with nonsteroidal anti-inflammatory drugs, glucocorticoids, Colchicin. The choice of drugs for the treatment of an acute attack of gout depends on the severity of the disease, on the presence of comorbidity, the presence of complications of chronic diseases, allergies and individual tolerability of drugs.
During an acute attack of gout, it is necessary to provide the patient's leg (arm) with an elevated position and complete rest.
For the treatment of acute gout, hormonal preparations of the synthetic group are used, which are virtually identical to the human hormones that are produced by the adrenal glands. Due to the influence of active substances, the chains of automatic reactions of the immune system to the effects of allergic components, chemicals and harmful organisms break.
This property allows you to instantly arrest the crisis and aggravation caused by gout, which quickly relieves pain and eliminates discomfort. Most commonly, corticosteroids such as Cortisone, Prednisone, Prednisolone and others are used to relieve seizures. They are administered by injection into the immediate focus of the disease.
Dosages of corticosteroids for gout are selected only individually after an on-site examination by a specialist. Usually, the pain after the injection begins to subside after the first use. This allows you to shorten the course of therapy.
Prednisone 20 mg tablet
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Buying Prednisone 20 mg tablets in online stores
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It is known that some online pharmacies give their customers a discount when they buy Prednisone 20 mg tablets through their website. This discount is sent within the next three days either to the personal account of the store, or by e-mail in the form of a coupon for the next purchase of drugs. Online pharmacies can also save a lot with the help of various bonus systems and cashback services.
The composition of the drug Prednisolone acetate
Active ingredient - Prednisolone.
Suspension for injection 25mg / ml.
Drugs with glucocorticosteroid activity.
Prednisolone acetate is an anti-inflammatory, antiallergic, immunosuppressive medication. Prednisolone acetate affects various types of metabolism: has a catabolic effect, increases blood glucose levels, promotes the redistribution of adipose tissue, causes sodium and water retention in the body.
Prednisolone acetate inhibits the secretion of adrenocorticotropic hormone by the pituitary gland, thereby inhibiting the synthesis of glucocorticoids and androgens by the adrenal glands. Prednisolone acetate reduces the absorption of calcium in the intestine, increases its leaching from the bones and excretion by the kidneys. The drug is biotransformed by oxidation mainly in the liver, as well as in the kidneys, small intestine and bronchi.
After ingestion, Prednisolone acetate is rapidly absorbed in the gastrointestinal tract. Bioavailability is high. The maximum concentration of prednisolone acetate in the blood plasma is reached within 1-2 hours. Binding to blood proteins is high. The half-life is 2-3.5 hours. The drug is excreted in the urine in the form of inactive metabolites.
Indications for use of Prednisolone acetate
- Systemic diseases of the connective tissue,
- systemic vasculitis,
- bronchial asthma,
- asthmatic status bronchitis,
- liver disease,
- ulcerative colitis,
- nephrotic syndrome,
- toxic neuropathy,
- allergic diseases adrenogenital syndrome autoimmune hepatitis,
- Addison's disease,
- immune hemolytic anemia,
- exfoliative dermatitis,
- seborrheic dermatitis,
- allergic conjunctivitis and blepharitis,
- corneal inflammation,
- scleritis and episcleritis,
- sympathetic ophthalmia,
- chronic arthritis,
- rheumatic myocarditis and pericarditis,
- Dupuytren's contracture.
Contraindications to the use of Prednisolone acetate
- Peptic ulcer,
- decompensated diabetes,
- severe hypertension,
- active form of tuberculosis,
- Cushing's disease,
- systemic mycoses,
- acute viral infection,
- productive symptoms in mental illness;
- Viral and bacterial diseases of the eye, primary glaucoma, corneal diseases with epithelial damage;
- Bacterial, fungal, viral skin lesions,
- skin tumors,
Cautions when using Prednisolone Acetate
Prednisolone acetate is prescribed during the day, taking into account the circadian rhythm of endogenous corticosteroid secretion (at 6-8 o'clock in the morning). In the course of treatment, observation of an oculist, monitoring of blood pressure, water-electrolyte balance, plasma sugar levels, and regular analyzes of peripheral blood cells are necessary.
To reduce side effects, the effective administration of anabolic steroids, as well as an increase in potassium intake. In Addison's disease, the simultaneous use of barbiturates should be avoided.
For non-specific infections and tuberculosis, Prednisolone Acetate is used with caution. Upon completion of the course is recommended to consider the need for the introduction of adrenocorticotropic hormone.
Prednisolone for kids
The best medicine for the rapid clearance of allergies in kids and adults is Prednisolone.
Prednisolone belongs to the group of glucocorticoids.
This drug has a number of positive properties, due to which in a short time the body begins to work as usual.
Antiallergic effect of the drug Prednisolone is manifested by the following actions on the child's body:
- Suppression of the release of immediate type allergy mediators;
- Decrease in the level of basophils, lymphocytes, eosinophils, monocytes and an increase in platelets, red blood cells;
- Alleviation of allergies by elimination from shock, improving the functioning of the central nervous system, cleansing the body of toxins, reducing the release of hormones;
- Reducing the permeability of capillaries (small blood vessels), the fall in the number of basophils, it helps reduce the itching, swelling that are present in all allergies;
- Prednisolone suppresses excessive manifestation of the immune system, which leads to the development of allergic reactions in kids.
Ways to use Prednisolone for kids
- Inside: pills.
- Injections: intramuscular (intramuscular), intravenous (intravenous - jet, drop), intramuscular (intra-articular) - solution, suspension of the preparation for injection.
- Locally: eye suspensions, ointments.
How to take Prednisone for allergies in kids
Approximate intravenous doses of prednisone for children:
- For newborns - 2-3 mg / kg;
- For kids of preschool age - 1-2 mg per kg;
- For children of school age - 1-2 mg / kg.
It is useful to use Prednisolone ointment for eczema, psoriasis, atypical dermatitis, seborrhea.
Dosage of Prednisolone
Tablet form of the drug (taken orally, without chewing, washed down with water):
- Adults are recommended to take from 20 to 30 mg / day, with the transition to 5-10 mg.
- The initial dose for children should not exceed 1–2 mg / kg / day (for 4–6 doses), the maintenance dose - 300–600 mg / kg per day.
To discontinue therapeutic treatment, the dose of the drug Prednisolone is consistently reduced.
Solutions of prednisolone for injection with shock are introduced:
- Adults: 30-90 mg (1-3 ml) intravenously slowly or drip. 150-300 mg in critical conditions. If intravenous administration is not possible, intramuscular injection is given.
- Kids: 2–12 months - 2-3 mg / kg; 1–14 years old — 1–2 mg / kg IV slowly. After 20 - 30 minutes, the dose can be repeated.
Prednisolone can not be diluted in any injection solutions.
- Eye drops: apply 3 times a day, instilling 1–2 drops.
- Ointment should be applied 1-3 times a day, a thin layer on the damaged skin of the child. Occlusive dressings are applied on limited foci of the body to improve the effect.
The course of treatment is two maximum 3 weeks.
The drug Prednisolone is best used for a short time and in minimal doses, as it can provoke a slowdown in the growth of the child.
Using the drug it is necessary to monitor the development and growth in children.